Multivariate studies indicated that older many years, male sex, high-GTP level, and you may higher FIB-4 Index had been independent issues on the growth of HCC once reaching SVR

Dining table step 3. Univariate and you can multivariate analyses using Cox proportional danger regression out-of standard facts of growth of HCC throughout the 274 people without previous treatment of HCC.

The rate off development of HCC just after conclusion regarding SVR from the first-age bracket DAA cures is 7.4% (), as the speed regarding growth of HCC immediately after end off SVR by second-generation DAA treatment are nine.1% (), perhaps not rather more between the two teams (P = 0.677).

Brand new cumulative chance out-of HCC immediately following achieving SVR try checked out in the 274 patients instead a history of solution to HCC. The newest collective HCC occurrence pricing was in fact 2.1%, 5.9%, seven.0%, 9.1%, and you can several.9% for men on step 1, dos, step 3, 4, and 5 years, correspondingly, weighed against 0.9%, 0.9%, dos.3%, 2.3%, and 2.3% for women, proving reduced rates regarding HCC (P = 0.029, Fig step 3). The suitable cutoff really worth for anticipating the introduction of HCC into the this type of 274 people try ?0.214 by ROC investigation (susceptibility = 75.0%; specificity = 72.5%; AUC = 0.800, Fig cuatro).